Research - Laboratory/Non-Laboratory, Research Support - Laboratory/Non-Laboratory, Staff/Administrative
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Pennâ™s distinctive interdisciplinary approach to scholarship and learning.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
Posted Job Title
Reagent Formulation Technologist A
Job Profile Title
Resource Technologist A
Job Description Summary
At Penn, the Clinical Cell and Vaccine Production Facility (CVPF) is a cellular manufacturing facility accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a CCI Department of Pathology/Lab Medicine shared resource. The CVPF has two cellular manufacturing suites: one in the Ravdin Pavilion in the Hospital of the University of Pennsylvania (HUP) and a second in the Center for Advanced Cellular Therapeutics (CACT) in the South Pavilion Expansion of the Perelman Center for Advanced Medicine. The CVPF manufactures cell immunotherapy products in support of many investigational new drug (IND) protocols; all products undergo rigorous quality testing prior to approval of release for infusion.
Our vision is to produce high quality innovative cell therapies that advance the field and improve the lives of patients with unmet needs. In 2014, Pennâ™s immunotherapy for leukemia was awarded the FDAâ™s Breakthrough Therapy designation. In 2017, in an historic action the therapy was the first cellular therapy approved by the FDA. In 2018, the therapy was also approved for diffuse large B-cell lymphoma (DLBCL). Penn is a center of excellence for immunotherapies and the CVPF continues to support the development of personalized cell and gene therapies.
The focus of this role is to formulate growth media and reagents to support cell and gene therapy clinical trials at the Clinical Cell and Vaccine Production Facility (CVPF) and Center for Advanced Cellular Therapies (CACT) of the University of Pennsylvania.Â Reagent Formulation responsibilities include:
Formulation of media and reagents required for the clinical scale processing of cells
Assist the Reagent Formulation Lead
Prepare serum, media and reagent aliquots
Maintain minimum inventory of media and reagent stock
Receipt and storage of incoming apheresis material
Release final products for infusion
Maintain sample inventory database
Prepare growth curves for clinical and validation studies
Preparation of cell processing kits for cell manufacturing
Follow established Standard Operating Procedures in ISO Class 5, 7 and 8 cleanroom environments
Follow Good Documentation Practices (GDP)
Exceptional communication and organizational skills and strong attention to detail are required in this role. Previous experience in tissue culture is preferred.Â Previous experience working in clinical trials and in particular, cellular manufacturing is preferred.Â Efficient time management is essential.Â Routine interaction with manufacturing technicians, quality control scientists, quality assurance personnel, and support staff is necessary.Â This position is an Essential University employee and is required to report to work in times of inclement weather and University closure.Â Flexibility to work weekends is required.Â It is possible that this position may include an alternate shift/work week.Â A commitment of two years is expected in this role.Â
Qualifications: Bachelorâ™s degree in Biology or related science required. A minimum of 6 months cell culture experience is required, or equivalent combination of education and experience.Â Ability to work effectively in a fast-paced environment and consistently meet deadlines is required.Â Flexibility, Dedication, Accountability and Team-oriented interpersonal skills are essential in this position.Â Position may require âœoff-standard hoursâ and âœon-callâ hours related to specific clinical trials, including some nighttime or weekend hours; may require overtime.
Working Conditions Office, library, computer room; Stockroom or warehouse; Requires extensive safety training; Exposure to chemicals; Requires protective devices; Alternative work schedules
Physical Effort Typically sitting at a desk or table; Occasional lifting 25-50 lb.; Typically standing or walking; Typically bending, crouching, stooping; Intermittently sitting/standing/stooping; Using tools requiring high dexterity
This position is contingent upon funding.
Job Location - City, State
Department / School
Perelman School of Medicine
$32,000.00 - $57,600.00
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Internal Number: JR00005613
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.